Clp Protease 3D structures

3D structures of Clp protease

Updated on 24-November-2022

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• Clp P subunit or ATP-dependent Clp protease proteolytic subunit
  • 1tg6 - hClpP – human
    
  • 1tyf, 1yg6 – EcClpP – Escherichia coli
    
  • 1yg8, 3hln - EcClpP (mutant)
    
  • 1y7o – SpClpP – Streptococcus pneumonia
    
  • 2f6i, 4gm2, 4hnk – ClpP – Plasmodium falciparum
    
  • 2cby, 2ce3, 2c8t, 4u0h, 5e0s, 5dzk - MtClpP – Mycobacterium tuberculosis
    
  • 6mx2 – CdClpP1 - Clostridium difficile
    
  • 3ktg, 3kth, 3tt6 – BsClpP – Bacillus subtilis
    
  • 7feq, 7fes - BsClpP – Cryo EM
    
  • 3q7h - ClpP – Coxiella burnetii
    
  • 3qwd, 3st9, 3sta, 3v5e, 4emm, 4mxi - SaClpP – Staphylococcus aureus
    
  • 3v5i, 4emp, 5c90, 6dkf - SaClpP (mutant)
    
  • 2zl0 - HpClpP – Helicobacter pylori
    
  • 2zl3 - HpClpP (mutant)
    
  • 4jcq, 4jct, 4ryf – LmClp – Listeria monocytogenes
    
  • 6sfx - LmClpP – Cryo EM
    
  • 4jcr - LmCLP (mutant)
    
  • 5g1s, 5g1r, 5g1q, 3p2l - ClpP – Francisella tularensis
    
  • 6naq – NmClpP – Neisseria meningitidis
    
  • 7kr2 - NmClpP – Cryo EM
    
  • 6pbu – ClpP – Mycobacterium smegmatis
    
  • 7m1l, 7m1m – ClpP – Pseudomonas aeruginosa
    
  • 6x60 – ClpP2 – Chlamydia trachomatis
    
  • 7dft – XoClpP – Xanthomonas oryzae
    
• Clp P subunit binary complex
  • 6h23 - hClpP (mutant) + carboxamide derivative
    
  • 6dl7, 7vp9, 7wh5 - hClpP + pyrimidine derivative
    
  • 6bba - hClpP + ADEP-28
    
  • 2fzs, 3mt6 - EcClpP + ADEP-1
    
  • 6ppe – EcClpP + ClpX – Cryo EM
    
  • 7mk5 – EcClpP + inhibitor
    
  • 2zl2 - HpClpP + peptide
    
  • 2zl4 - HpClpP (mutant) + peptide
    
  • 3kti, 3ktj, 3ktk - BsClpP + ADEP-1
    
  • 3tt7 - BsClpP + DFP
    
  • 4u0g – MtClpP + ADEP + agonist
    
  • 5dl1, 6l40 – SaClpP + inhibitor
    
  • 5w18, 5vz2, 6pka, 6pmd – SaClpP + peptide
    
  • 7wgs, 7wid, 7xbz – SaClpP + activator
    
  • 5dkp – NmClpP + ADEP
    
  • 6nah - NmClpP + ADEP-14
    
  • 7fep, 7fer – BsClpP + ADEP1 – Cryo EM
    
  • 7p80, 7p81 – BsClpP + ADEP2
    
  • 6vxf - NmClpP + ClpX + ADP + ATP – Cryo EM
    
  • 6cfd – ClpP + ADEP-4 – Enterococcus faecium
    
  • 7dfu – XoClpP + ADEP-4
    
  • 6hwn – ClpP + tripeptide – Thermus thermophilus
    
• CLP C
  • 5gui – ClpC1 N terminal – Arabidopsis thaliana
    
  • 3fes - CdClpC
    
  • 6pbq - MtClp N-terminal domain
    
  • 8a8u, 8a8v, 8a8w - MtClp + antibiotic + ADP
    
  • 6cn8, 6pbs - MtClp N-terminal domain 1-145 + antibiotics
    
  • 6em8, 6em9 - SaClp – Cryo EM
    
• Clpx or ATP-dependent Clp protease ATP-binding subunit ClpXP
  • 6pba - MtClp N-terminal domain
    
  • 3hte, 4i34, 4i5o, 4i63, 4i9k - EcClp
    
  • 3hws, 4i4l - EcClp + ADP
    
  • 4i81 - EcClp + ATPgS
    
  • 6pp5 - EcClp + ADP – Cryo EM
    
  • 6pp6, 6pp7, 6pp8 - EcClp + ADP + ATPgS – Cryo EM
    
  • 6sfw - LmClp - Cryo EM
    
  • 6lsy - SpClp - Cryo EM
    
  • 6lt4 - SpClp + ATPgS – Cryo EM
    

For CLP A subunit and CLP N see Heat Shock Proteins Hsp100

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Michal Harel, Jaime Prilusky, Openfox