8b10 | pdb_00008b10

Crystal Structure of Shank2-SAM mutant domain - L1800W

spinqualitylabelsall models 8b10, resolution 1.95Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8b10 is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BTB, CL, PEG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease SHAN2_HUMAN NON RARE IN EUROPE: Autism. Disease susceptibility is associated with variants affecting the gene represented in this entry. Function SHAN2_HUMAN Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

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