8e9w | pdb_00008e9w

CryoEM structure of miniGq-coupled hM3Dq in complex with DCZ

spinqualitylabelsall models 8e9w, resolution 2.69Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8e9w is a 5 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: WEC Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease ACM3_HUMAN Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:100100. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities. Function ACM3_HUMAN The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

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