8ea0 | pdb_00008ea0

CryoEM structure of miniGq-coupled hM3R in complex with iperoxo (local refinement)

spinqualitylabelsall models 8ea0, resolution 2.56Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8ea0 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: IXO, Y01 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease ACM3_HUMAN Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:100100. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities. Function ACM3_HUMAN The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

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