| Structural highlights
Function
VGLU2_RAT Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. May also mediate the transport of inorganic phosphate.[1] [2] [3] [4] [5] [6]
References
- ↑ Fremeau RT Jr, Troyer MD, Pahner I, Nygaard GO, Tran CH, Reimer RJ, Bellocchio EE, Fortin D, Storm-Mathisen J, Edwards RH. The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron. 2001 Aug 2;31(2):247-60. PMID:11502256
- ↑ Hayashi M, Otsuka M, Morimoto R, Hirota S, Yatsushiro S, Takeda J, Yamamoto A, Moriyama Y. Differentiation-associated Na+-dependent inorganic phosphate cotransporter (DNPI) is a vesicular glutamate transporter in endocrine glutamatergic systems. J Biol Chem. 2001 Nov 16;276(46):43400-6. Epub 2001 Sep 10. PMID:11551935 doi:https://dx.doi.org/10.1074/jbc.M106244200
- ↑ Herzog E, Bellenchi GC, Gras C, Bernard V, Ravassard P, Bedet C, Gasnier B, Giros B, El Mestikawy S. The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons. J Neurosci. 2001 Nov 15;21(22):RC181. PMID:11698619
- ↑ Takamori S, Rhee JS, Rosenmund C, Jahn R. Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2). J Neurosci. 2001 Nov 15;21(22):RC182. PMID:11698620
- ↑ Juge N, Yoshida Y, Yatsushiro S, Omote H, Moriyama Y. Vesicular glutamate transporter contains two independent transport machineries. J Biol Chem. 2006 Dec 22;281(51):39499-506. Epub 2006 Oct 17. PMID:17046815 doi:https://dx.doi.org/M607670200
- ↑ Mackenzie B, Illing AC, Morris ME, Varoqui H, Erickson JD. Analysis of a vesicular glutamate transporter (VGLUT2) supports a cell-leakage mode in addition to vesicular packaging. Neurochem Res. 2008 Feb;33(2):238-47. Epub 2007 Dec 13. PMID:18080752 doi:https://dx.doi.org/10.1007/s11064-007-9546-z
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