8egs | pdb_00008egs

Tail knob structure of Staphylococcus phage Andhra

spinqualitylabelsall models 8egs, resolution 3.92Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8egs is a 3 chain structure with sequence from Rakietenvirinae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A1S6L1I1_9CAUD Publication Abstract from PubMed Staphylococcus epidermidis is an opportunistic pathogen of the human skin, often associated with infections of implanted medical devices. Staphylococcal picoviruses are a group of strictly lytic, short-tailed bacteriophages with compact genomes that are attractive candidates for therapeutic use. Here, we report the structure of the complete virion of S. epidermidis-infecting phage Andhra, determined using high-resolution cryo-electron microscopy, allowing atomic modeling of 11 capsid and tail proteins. The capsid is a T = 4 icosahedron containing a unique stabilizing capsid lining protein. The tail includes 12 trimers of a unique receptor binding protein (RBP), a lytic protein that also serves to anchor the RBPs to the tail stem, and a hexameric tail knob that acts as a gatekeeper for DNA ejection. Using structure prediction with AlphaFold, we identified the two proteins that comprise the tail tip heterooctamer. Our findings elucidate critical features for virion assembly, host recognition, and penetration. Structure and host specificity of Staphylococcus epidermidis bacteriophage Andhra.,Hawkins NC, Kizziah JL, Hatoum-Aslan A, Dokland T Sci Adv. 2022 Dec 2;8(48):eade0459. doi: 10.1126/sciadv.ade0459. Epub 2022 Nov , 30. PMID:36449623 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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