4m1b | pdb_00004m1b

Structural Determination of BA0150, a Polysaccharide Deacetylase from Bacillus anthracis

spinqualitylabelsall models 4m1b, resolution 1.99Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4m1b is a 2 chain structure with sequence from Bacillus anthracis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: PGE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A6L7HRJ6_BACAN Publication Abstract from PubMed Polysaccharide deacetylases are bacterial enzymes that catalyze the deacetylation of acetylated sugars on the membranes of Gram-positive bacteria, allowing them to be unrecognized by host immune systems. Inhibition of these enzymes would disrupt such pathogenic defensive mechanisms and therefore offers a promising route for the development of novel antibiotic therapeutics. Here, the first X-ray crystal structure of BA0150, a putative polysaccharide deacetylase from Bacillus anthracis, is reported to 2.0 A resolution. The overall structure maintains the conserved (alpha/beta)8 fold that is characteristic of this family of enzymes. The lack of a catalytic metal ion and a distinctive metal-binding site, however, suggest that this enzyme is not a functional polysaccharide deacetylase. Structure determination of BA0150, a putative polysaccharide deacetylase from Bacillus anthracis.,Strunk RJ, Piemonte KM, Petersen NM, Koutsioulis D, Bouriotis V, Perry K, Cole KE Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):156-9. doi:, 10.1107/S2053230X13034262. Epub 2014 Jan 21. PMID:24637747 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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