4m4v | pdb_00004m4v

Structural evaluation R171L mutant of the aspergillus fumigatus kdnase (sialidase)

spinqualitylabelsall models 4m4v, resolution 1.84Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4m4v is a 2 chain structure with sequence from Aspergillus fumigatus Af293. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: DAN, GOL, NA, NO3 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SIA_ASPFU Sialidase is able to release sialic acid from a wide variety of natural substrates including bovine salivary mucin, colominic acid, bovine fetuin, a serum glycoprotein containing both alpha-2-6 and alpha-2-3-linkages in a ratio of about 3:2, and glycoproteins and glycolipids from thermally denatured human lung epithelial cells. Does not show any trans-sialidase activity since it is able to remove terminal sialic acid residues but is unable to catalyze their transfer to the acceptor substrate. 2-keto-3-deoxynononic acid (KDN) is the preferred substrate and A.fumigatus can utilize KDN as a sole carbon source.

Proteopedia Page Contributors and Editors (what is this?)

OCA