7quj | pdb_00007quj

Structure of NsNEPS2, a 7S-cis-trans nepetalactone synthase

spinqualitylabelsall models 7quj, resolution 1.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7quj is a 4 chain structure with sequence from Nepeta sibirica. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NAD Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Thousands of natural products are derived from the fused cyclopentane-pyran molecular scaffold nepetalactol. These natural products are used in an enormous range of applications that span the agricultural and medical industries. For example, nepetalactone, the oxidized derivative of nepetalactol, is known for its cat attractant properties as well as potential as an insect repellent. Most of these naturally occurring nepetalactol-derived compounds arise from only two out of the eight possible stereoisomers, 7S-cis-trans and 7R-cis-cis nepetalactols. Here we use a combination of naturally occurring and engineered enzymes to produce seven of the eight possible nepetalactol or nepetalactone stereoisomers. These enzymes open the possibilities for biocatalytic production of a broader range of iridoids, providing a versatile system for the diversification of this important natural product scaffold. Biocatalytic routes to stereo-divergent iridoids.,Hernandez Lozada NJ, Hong B, Wood JC, Caputi L, Basquin J, Chuang L, Kunert M, Rodriguez Lopez CE, Langley C, Zhao D, Buell CR, Lichman BR, O'Connor SE Nat Commun. 2022 Aug 11;13(1):4718. doi: 10.1038/s41467-022-32414-w. PMID:35953485 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Proteopedia Page Contributors and Editors (what is this?)

OCA