4mks | pdb_00004mks

Crystal structure of enolase from Lactobacillus gasseri

spinqualitylabelsall models 4mks, resolution 2.08Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4mks is a 2 chain structure with sequence from Lactobacillus gasseri ATCC 33323 = JCM 1131. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ENO2_LACGA Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity). Publication Abstract from PubMed Enolases are highly conserved metalloenzymes ubiquitous to cellular metabolism. While these enzymes share a large degree of sequence and structural similarity, they have been shown to possess a wide range of moonlighting functions. Recent studies showed that an enolase from Lactobacillus gasseri impedes the ability of Neisseria gonorrhoeae to adhere to epithelial cells. We present the crystal structure of this enolase, the first from Lactobacillus, with one of its Mg2+ cofactors. Determined using molecular replacement to 2.08A, the structure has a flexible and surface exposed catalytic loop containing lysines, and may play a role in the inhibitory function. Crystal structure of an efficacious gonococcal adherence inhibitor: An enolase from Lactobacillus gasseri.,Raghunathan K, Harris PT, Spurbeck RR, Arvidson CG, Arvidson DN FEBS Lett. 2014 May 21. pii: S0014-5793(14)00392-5. doi:, 10.1016/j.febslet.2014.05.020. PMID:24859038 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Enolase 3D structures

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