4n5b | pdb_00004n5b

Crystal structure of the Nipah virus phosphoprotein tetramerization domain

spinqualitylabelsall models 4n5b, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4n5b is a 8 chain structure with sequence from Nipah henipavirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: IMD Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function D2DEB8_NIPAV Publication Abstract from PubMed The Nipah virus phosphoprotein, P, is multimeric and tethers the viral polymerase to the nucleocapsid. We present the crystal structure of the multimerization domain of Nipah P: a long, parallel, tetrameric, coiled coil with a small, alpha-helical cap structure. Across the paramyxoviruses, these domains share little sequence identity; yet retain similar length and structural organization, suggesting a common requirement for scaffolding or spatial organization of the functions of P in the virus life cycle. Crystal structure of the Nipah virus phosphoprotein tetramerization domain.,Bruhn-Johannsen JF, Barnett K, Bibby J, Thomas J, Keegan R, Rigden D, Bornholdt ZA, Saphire EO J Virol. 2013 Oct 23. PMID:24155387 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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