7t90 | pdb_00007t90

Cryo-EM structure of ACh-bound M2R-Go signaling complex in S2 state

spinqualitylabelsall models 7t90, resolution 3.32Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7t90 is a 5 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ACH Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease ACM2_HUMAN Disease susceptibility is associated with variations affecting the gene represented in this entry. Function ACM2_HUMAN The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.

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