4od5 | pdb_00004od5

Substrate-bound structure of a UbiA homolog from Aeropyrum pernix K1

spinqualitylabelsall models 4od5, resolution 3.56Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4od5 is a 6 chain structure with sequence from Aeropyrum pernix K1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GST, MG, PHB Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9YBM8_AERPE Publication Abstract from PubMed Biosynthesis of ubiquinones requires the intramembrane UbiA enzyme, an archetypal member of a superfamily of prenyltransferases that generates lipophilic aromatic compounds. Mutations in eukaryotic superfamily members have been linked to cardiovascular degeneration and Parkinson's disease. To understand how quinones are produced within membranes, we report the crystal structures of an archaeal UbiA in its apo and substrate-bound states at 3.3 and 3.6 angstrom resolution, respectively. The structures reveal nine transmembrane helices and an extramembrane cap domain that surround a large central cavity containing the active site. To facilitate the catalysis inside membranes, UbiA has an unusual active site that opens laterally to the lipid bilayer. Our studies illuminate general mechanisms for substrate recognition and catalysis in the UbiA superfamily and rationalize disease-related mutations in humans. Structural insights into ubiquinone biosynthesis in membranes.,Cheng W, Li W Science. 2014 Feb 21;343(6173):878-81. doi: 10.1126/science.1246774. PMID:24558159 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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