7qyr | pdb_00007qyr

Crystal structure of RimK from Pseudomonas aeruginosa PAO1

spinqualitylabelsall models 7qyr, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7qyr is a 16 chain structure with sequence from Pseudomonas aeruginosa PAO1 and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ADP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RIMK_PSEAE Publication Abstract from PubMed Bacteria are equipped with a diverse set of regulatory tools that allow them to quickly adapt to their environment. The RimK system allows for Pseudomonas spp. to adapt through post-transcriptional regulation by altering the ribosomal subunit RpsF. RimK is found in a wide range of bacteria with a conserved amino acid sequence, however, the genetic context and the role of this protein is highly diverse. By solving and comparing the structures of RimK homologs from two related but functionally divergent systems, we uncovered key structural differences that likely contribute to the different activity levels of each of these homologs. Moreover, we were able to clearly resolve the active site of this protein for the first time, resolving binding of the glutamate substrate. This work advances our understanding of how subtle differences in protein sequence and structure can have profound effects on protein activity, which can in turn result in widespread mechanistic changes. Structural insights into the mechanism of adaptive ribosomal modification by Pseudomonas RimK.,Thompson CMA, Little RH, Stevenson CEM, Lawson DM, Malone JG Proteins. 2022 Sep 22. doi: 10.1002/prot.26429. PMID:36134899 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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