Ephrin receptor 3D structures

3D Structures of ephrin receptors

Updated on 21-February-2023

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• Ephrin A1 receptor
  • 3kka - hEPHR A1 SAM+ hEPH A2 SAM – human
    
  • 3hil - hEPHR A1 SAM
    
  • 2k1l, 2k1k - hEPHR A1 transmembrane domain – NMR
    
  • 1x5a - hEPHR A1 fn3 domain – NMR<BR
• Ephrin A2 receptor; domains – LBD 28-200; ectodomain 27-435; kinase 596-900; SAM fragment 945-969
  • 3hpn, 3c8x - hEPHR A2 LBD
    
  • 2x10, 3fl7 - hEPHR A2 ectodomain
    
  • 2k9y, 2e8n - hEPHR A2 transmembrane domain – NMR
    
  • 1mqb, 4p2k, 4pdo, 4trl, 5ek7, 5i9u - hEPHR A2 kinase domain
    
  • 7kja - hEPHR A2 kinase+SAM domains
    
  • 7kjb, 7kjc - hEPHR A2 kinase+SAM domains (mutant)
    
• Ephrin A2 receptor binary complex
  
  • 3mx0, 2x11 - hEPHR A2 ectodomain + ephrin A5
    
  • 3hei, 3czu - hEPHR A2 LBD + ephrin A1
    
  • 3mbw - hEPHR A2 LBD + carbohydrate-recognition domain + ephrin A1
    
  • 6njz, 6nk0, 6nk1, 6nk2, 6nkp, 6b9l - hEPHR A2 LBD + peptide
    
  • 6rw2 - hEPHR A2 LBD + bicycle toxin
    
  • 7b7n, 7cze, 7czf - hEPHR A2 LBD + herpesvirus glycoproteins
    
  • 2kso - hEPHR A2 SAM fragment residues 945-969 + SHIP2
    
  • 5nz9 - hEPHR A2 SAM fragment - NMR
    
  • 6f7m, 6f7n - hEPHR A2 SAM fragment (mutant) - NMR
    
  • 5i9v, 5i9w, 5njz, 5nk0, 5nk1, 5nk2, 5nk3, 5nk4, 5nk5, 5nk6, 5nk7, 5nk8, 5nk9, 5nka, 5nkb, 5nkc, 5nkd, 5nke, 5nkf, 5nkg, 5nkh, 5nki, 6hes, 6het, 6heu, 6hev, 6hew, 6hex, 6hey, 6q7b, 6q7c, 6q7d, 6q7e, 6q7f, 6q7g, 8bin, 8bio, 8bk0 - hEPHR A2 kinase domain + inhibitor
    
  • 6fnf, 6fng, 6fnh – hEPHR A2 kinase domain + pyrimidine derivative
    
  • 5i9x, 5i9y, 5i9z, 5ia0, 5ia1, 5ia2, 5ia3, 5ia4, 5ia5 - hEPHR A2 kinase domain + kinase drug
    
• Ephrin A3 receptor
  • 2qo2, 2qob, 2gsf - hEPHR A3 kinase domain
    
  • 2qok, 2qol, 2qon, 2qoo, 2qod, 2qof, 2qoi - hEPHR A3 kinase domain (mutant)
    
  • 3fxx, 3fy2 – hEPHR A3 kinase domain + peptide substrate
    
  • 2qoq, 2qo7, 2qo9, 2qoc - hEPHR A3 kinase domain + AMP-PNP
    
  • 3dzq, 4gk2, 4gk3, 4gk4, 4p5q, 4p5z, 4p4c, 4twn, 4two, 6in0 - hEPHR A3 kinase domain + inhibitor
    
  • 4g2f - hEPHR A3 kinase domain (mutant) + inhibitor
    
  • 4l0p - hEPHR A3 LBD + Ephrin-A5
    
• Ephrin A4 receptor
  • 2wo1, 3ckh - hEPHR A4 LBD
    
  • 4bk4, 4m4p - hEPHR A4 ectodomain
    
  • 2lw8 - hEPHR A4 LBD – NMR
    
  • 7ofv - hEPHR A4 LBD + polypeptide inhibitor
    
  • 6fnl – hEPHR A4 kinase domain
    
  • 2hel – mEPHR A4 membrane and kinase domains – mouse
    
  • 2y6m – mEPHR A4 kinase domain
    
• Ephrin A4 receptor binary complex
  
  • 2wo3 - hEPHR A4 LBD + ephrin A2 receptor-binding domain
    
  • 4w4z, 4w50, 5jr2 - hEPHR A4 LBD (mutant) + peptide
    
  • 2wo2, 3gxu - hEPHR A4 LBD + ephrin B2 receptor-binding domain
    
  • 4bk5, 4bka, 4m4r - hEPHR A4 ectodomain + ephrin A5 LBD
    
  • 4bkf - hEPHR A4 ectodomain + ephrin B3 LBD
    
  • 6fnm – hEPHR A4 kinase domain + dasatinib
    
  • 6fni, 6fnj, 6fnk – hEPHR A4 kinase domain + pyrimidine derivative
    
  • 2xyu – mEPHR A4 kinase domain + inhibitor
    
  • 2y6o – mEPHR A4 kinase domain + cancer drug
    
• Ephrin A5 receptor
  • 2r2p - hEPHR A5 kinase domain
    
  • 4et7 – hEPHR A5 LBD (mutant)
    
  • 1shx - mEPHR A5
    
  • 5zrz – mEPHR SAM domain + SAMD5
    
• Ephrin A7 receptor
  • 3nru – hEPHR A7 LBD
    
  • 3h8m – hEPHR A7 SAM
    
  • 2rei - hEPHR A7 kinase domain
    
  • 7eec, 7eed, 7eef - hEPHR A7 kinase domain (mutant)
    
  • 3dko – hEPHR A7 kinase domain + inhibitor
• Ephrin A8 receptor
  • 3kul - hEPHR A8 kinase domain
    
  • 1x5l – hEPHR A8 fn3 domain – NMR
    
  • 1ucv - hEPHR A8 SAM – NMR
    
• Ephrin B1 receptor
  • 2eao – hEPHR B1 SAM – NMR
    
  • 2djs - hEPHR B1 fn3 domain – NMR
    
  • 3zfx - hEPHR B1 kinase domain residues 602-896
    
  • 5mja - hEPHR B1 kinase domain + inhibitor
    
  • 5mjb - hEPHR B1 kinase domain (mutant) + inhibitor
    
  • 6umw - hEPHR B1 kinase domain + antibiotics
    
  • 7kpl - hEPHR B1 172-450
    
  • 7kpm - hEPHR B1 172-450 + ADP
    
• Ephrin B2 receptor
  • 3etp – hEPHR B2
    
  • 1b4f - hEPHR B2 SAM
    
  • 1f0m – mEPHR B2 SAM
    
  • 1iko - mEPHR B2 ectodomain
    
  • 2i85 - hEPHR B2 ectodomain
    
  • 3zfm - hEPHR B2 kinase domain
    
  • 1sgg - mEPHR B2 SAM – chicken - NMR
    
• Ephrin B2 receptor binary complex
  
  • 2vsk, 2vsm – hEPHR B2 + Viral Hemagglutinin-neuraminidase
    
  • 2qbx – hEPHR B2 + peptide agonist
    
  • 2hen - hEPHR B2 kinase domain + ADP
    
  • 1shw - mEPHR B2 LBD + ephrin A5
    
  • 1kgy - mEPHR B2 LBD + ephrin B2 extracellular domain
    
• Ephrin B3 receptor
  • 3p1i – hEPHR B3 LBD
    
  • 3zfy - hEPHR B3 kinase domain
    
  • 5l6o, 5l6p - hEPHR B3 kinase domain (mutant) + inhibitor
    
• Ephrin B4 receptor
  • 2qkq – hEPHR B4 SAM
    
  • 2e7h – hEPHR B4 fn3 domain - NMR
    
  • 2x9f, 2vwy - hEPHR B4 kinase domain (mutant)
    
• Ephrin B4 receptor binary complex
  
  • 2vwx, 2vwz, 2vx0, 2vx1, 2vwu, 2vwv, 2vww, 4aw5 – hEPHR B4 kinase domain + inhibitor
    
  • 3zew - hEPHR B4 + staurosporine
    
  • 2xvd, 2yn8, 4bb4 - hEPHR B4 kinase domain (mutant) + inhibitor
    
  • 2hle, 2bba - hEPHR B4 LBD + ephrin B2
• Ephrin B6 receptor
  • 7k7j - hEPHR B6 ectodomain
    

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Michal Harel