8ia5 | pdb_00008ia5

Small peptide enhances the binding of nutline-3a to N-terminal domain of MdmX

spinqualitylabelsall models 8ia5, resolution 1.93Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8ia5 is a 2 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NUT, O4B Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MDM4_HUMAN Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.

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