Farnesyltransferase 3D structures

3D structures of farnesyltransferase

Updated on 27-February-2023

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• FTase
  • 1ft1 – rFTase – rat
    
  • 3q73 – CnFTase – Cryptococcus neoformans
• FTase binary complex with FPP
  • 1ft2, 1fpp – rFTase + FPP
    
  • 1o1r, 1o1s, 3ksl, 3ksq - rFTase + FPP-analog
    
• FTase binary complex with peptide
  • 1kzp, 1o1t - rFTase + farnesylated peptide
    
  • 2h6f - hFTase + farnesylated peptide
    
  • 2h6g, 2h6h, 2h6i - hFTase α subunit + β subunit (mutant) + farnesylated peptide
    
  • 3q79 - CnFTase + farnesylated peptide
• FTase binary complex with inhibitor
  • 3eu5 – rFTase + biotin-GPP
    
  • 3euv - rFTase α subunit + β subunit (mutant)+ biotin-GPP
    
  • 1n94, 1n95, 1n9a, 1o5m, 1ni1, 1x81, 2bed, 2r2l - rFTase + inhibitor
    
  • 1nl4 - rFTase α subunit (mutant) + β subunit + inhibitor
• FTase ternary complex with FPP and peptide
  • 1d8d, 1tn8 - rFTase + Ras peptide + FPP-analog
    
  • 1kzo - rFTase + farnesylated Ras peptide + FPP
    
  • 1tn7, 3dpy - rFTase + peptide + FPP-analog
    
  • 1jcr, 1jcs - rFTase + tetrapeptide inhibitor + FPP
    
  • 1d8e - rFTase no Zn + Ras peptide + FPP-analog
    
  • 1tn6 - hFTase + Rap2a peptide + FPP-analog
    
  • 3q75, 3q78 - CnFTase + peptide + FPP-analog
    
  • 4l9p - AfFTase + peptide + FPP-analog – Apergillus fumigatus
    
• FTase ternary complex with FPP and inhibitor
  • 1jcq – hFTase α subunit (mutant) + β subunit + inhibitor + FPP– human
    
  • 1ld7, 1ld8, 1mzc, 1sa4, 1s63, 2f0y - hFTase + inhibitor + FPP
    
  • 2iej - hFTase + inhibitor + FPP-analog
    
  • 1sa5, 3e30, 3e32, 3e33, 3e34, 3e37 - rFTase + inhibitor + FPP
    
  • 4gtm, 4gto, 4gtp, 4gtq, 4gtr, 8e9e - rFTase α subunit + β subunit + inhibitor + FPP
    
  • 2zir, 2zis - rFTase α subunit (mutant) + β subunit + inhibitor + FPP
    
  • 3pz4 - FTase + inhibitor + FPP – mouse
    
  • 3q7a, 3q7f, 7t08, 7t09, 7t0a, 7t0b, 7t0c, 7t0d, 7t0e - CnFTase + inhibitor + FPP
    
  • 3fsx, 3sfy - CnFTase + inhibitor + FPP-analog
    
  • 3sfx - CnFTase α subunit + β subunit + inhibitor + FPP
    
  • 4lnb, 4lng, 4mbg - AfFTase (mutant) + inhibitor + FPP
    
• FTase ternary complex with GPP and protein
  • 1n4p, 1n4r, 1n4s - rFTase α subunit + GTase β subunit + transforming protein + GPP
    

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Michal Harel