4rii | pdb_00004rii

Chimeric Glycosyltransferase LanGT2S8Ac, TDP complex

spinqualitylabelsall models 4rii, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4rii is a 2 chain structure with sequence from Streptomyces cyanogenus and Streptomyces fradiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MG, TYD Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9ZGC0_STRCY Q9RPA7_STRFR Publication Abstract from PubMed The structures of the O-glycosyltransferase LanGT2 and the engineered, CC bond-forming variant LanGT2S8Ac show how the replacement of a single loop can change the functionality of the enzyme. Crystal structures of the enzymes in complex with a nonhydrolyzable nucleotide-sugar analogue revealed that there is a conformational transition to create the binding sites for the aglycon substrate. This induced-fit transition was explored by molecular docking experiments with various aglycon substrates. Structural Characterization of O- and C-Glycosylating Variants of the Landomycin Glycosyltransferase LanGT2.,Tam HK, Harle J, Gerhardt S, Rohr J, Wang G, Thorson JS, Bigot A, Lutterbeck M, Seiche W, Breit B, Bechthold A, Einsle O Angew Chem Int Ed Engl. 2015 Jan 7. doi: 10.1002/anie.201409792. PMID:25581707 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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