Galactose-binding lectin

spinqualitylabelsall models Structure of peanut galactose-binding lectin tetramer complex withβ-D-galactose, α-D-glucose, Ca+2 (green) and Mn+2 (purple) ions (PDB entry 1v6i) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Galactose-binding lectin (GBL) is a lectin which binds the carbohydrate sequence Gal-β(1,3)-GalNac. GBL is an all beta-sheet protein. Relevance GBL is used in affinity columns for capturing proteins which are glycosylated with Gal-β(1,3)-GalNac. Structural highlights The carbohydrate ligand binds to 3 loops. β-D-galactose/α-D-glucose binding site in peanut galactose-binding lectin (PDB entry 1v6i). Ca coordination site. Mn coordination site. Water molecules shown as red spheres.

3D structures of galactose-binding lectin

Updated on 07-March-2023

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• Peanut GBL
  • 1v6i, 1v6m, 1v6n, 1v6o, 2dh1, 2dvf – GBL
    
• Peanut GBL binary complex
  • 1qf3 – GBL + methyl-β-galactose
    
  • 2dv9, 2dvd – GBL + β-D-galactose
    
  • 1rir – GBL + porphyrin derivative
    
  • 6v95, 6vav, 6vaw, 6vc3, 6vc4, 6vgf – GBL + galactopyranose derivative
    
• Peanut GBL ternary complex
  • 1v6i, 1v6j, 1v6k, 1cr7, 2dvg – GBL + β-D-galactose + α-D-glucose
    
  • 2pel – GBL + β-lactose + α-lactose
    
  • 2tep, 2dva, 2dvb – GBL + β-D-galactose + N-acetyl-D-galactosamine
    
  • 1ciw – GBL + β-D-galactose + 2-acetylamino-2-deoxy-D-glucopyranose
    
  • 1rit – GBL + porphyrin derivative + β-lactose
    
• Peanut GBL quaternary complex
  • 1bzw, 1v6l – GBL + β-D-galactose + α-D-glucose + β-D-glucose
    
• Pseudomonas aeruginosa GBL
  • 1l7l, 1uoj – GBL
    
  • 4cp9, 4cpb, 7z62, 7z63 – GBL + galactoside
    
  • 7fio, 7fjh – GBL + inhibitor
    
• PaGBL binary complex
  • 2wyf – GBL + methyl-β-galactose
    
  • 4ljh – GBL + β-D-galactose
    
  • 3zyf, 4a6s, 4yw6, 5mih – GBL + galactopyranose derivative
    
  • 4ywa – GBL + triazole derivative
    
  • 6yo3, 6yoh – GBL + oxidanyl derivative
    
• PaGBL ternary complex
  • 3zyh – GBL + galactopyranose derivative + gal-lys-pro-leu
    
  • 4yw7 – GBL + galactopyranose derivative + triazole derivative
    
  • 3zyb – GBL + β-D-galactose + gal-lys-pro-leu
    
  • 4lk6 – GBL + β-D-galactose + chlorophenol red
    
  • 4lk7 – GBL + β-D-galactose + resorufin
    
  • 1oko – GBL + β-D-galactose + α-D-galactose
    
  • 4al9 – GBL + α-D-galactose + α-D-glucose
    
• PaGBL quaternary complex
  • 2vxj – GBL + β-D-galactose + α-D-galactose + α-D-glucose + β-D-glucose
    
• Lumbricus terrestris GBL
  • 2dry – LtGBL C terminal (mutant) – Lumbricus terrestris
    
  • 2rst – LtGBL C terminal
    
  • 2drz – LtGBL C terminal (mutant) + lactose
    
  • 2zqn – LtGBL C terminal + lactose
    
  • 2ds0 – LtGBL C terminal (mutant) + sialyllactose
    
  • 2zqo – LtGBL C terminal + GalNac
    
• Other GBL
  • 5x4a, 3wmp, 3wmq – GBL residues 47-140 + polysaccharide – Sinularia lochmodes
    
  • 2zqn – eGBL C-terminal + lactose – earthworm
    
  • 2zqo – eGBL C-terminal + GalNac
    
  • 6yf6 – GBL C-terminal + fucoside derivative – Enterobacter cloacae
    
  • 5vbk, 6bfm – GBL - mussell
    

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