Sandbox Reserved 1769
From Proteopedia
Sodium-taurocholate Co-transporting Polypeptide
| ||||||||||||
References
ContentsIntroductionNTCP is found within the membrane of hepatocyte, and its primary role is to facilitate the transport of bile salts into hepatocytes from the bloodstream. This is important because 90% of human bile salts are recycled daily, no the function of NTCP is critical in providing bile salts to solubilize fats for digestion. There are two characteristic domains of NTCP, including the core domain and panel domain. There are also two different conformational states that have been identified that have implications for how the transport of bile salts occurs, although the exact molecular mechanism is not yet known. In addition to transporting bile salts into the cytoplasm of hepatocytes, NTCP also serves as a receptor for HBV and HDV virus. FunctionBile Salt UptakeHBV/HDV InfectionStructureProline/Glycine HingeCore & Panel DomainsSodium Binding SitesSignificant ResiduesMolecular MechanismMechanism of Bile Salt UptakeMechanism of HBV/HDV InfectionMedical RelevanceRelevanceThis is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
| ||||||||||||
This page was last modified 17:57, 13 March 2023.