2n9d | pdb_00002n9d

Structure analysis of the Tom1 GAT domain reveals distinct ligand-specific conformational states

spinqualitylabelsall models 2n9d Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2n9d is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function TOM1_HUMAN May be involved in intracellular trafficking. Probable association with membranes. Publication Abstract from PubMed Cellular homeostasis requires correct delivery of cell-surface receptor proteins (cargo) to their target subcellular compartments. The adapter proteins Tom1 and Tollip are involved in sorting of ubiquitinated cargo in endosomal compartments. Recruitment of Tom1 to the endosomal compartments is mediated by its GAT domain's association to Tollip's Tom1-binding domain (TBD). In this data article, we report the solution NMR-derived structure of the Tom1 GAT domain. The estimated protein structure exhibits a bundle of three helical elements. We compare the Tom1 GAT structure with those structures corresponding to the Tollip TBD- and ubiquitin-bound states. Structure of the GAT domain of the endosomal adapter protein Tom1.,Xiao S, Ellena JF, Armstrong GS, Capelluto DG Data Brief. 2016 Feb 24;7:344-8. doi: 10.1016/j.dib.2016.02.042. eCollection 2016, Jun. PMID:26977434 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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