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This page, as it appeared on June 14, 2016, was featured in this article in the journal Biochemistry and Molecular Biology Education.

Introduction

Lysophosphatidic Acid Receptor

• Lipid signaling
• Transmembrane (cell surface) receptors

Figure 1: LPA receptor (blue) bound to the cell membrane. The binding pocket is highlighted in red. The added bRIL protein is highlighted in orange.

Lysophosphatidic Acid

Figure 2: Chemical Structure of LPA (monoacyl-sn-glycero-3-phosphate)

Structure

Key Ligand Interactions

Figure 3: Electrostatic illustration of the amphipathic binding pocket of the LPA₁ receptor. This binding pocket was revealed by cutting away the exterior or the protein. This binding pocket, located in the interior of the protein, has both polar and nonpolar regions. The blue and red coloration highlight the positively and negatively charged regions, respectively, and the white color shows the nonpolar region of the binding pocket.

Receptor Comparison

Disease Relevance

3D structures of lysophosphatidic acid receptor

4z34, 4z35, 4z36 - hLPA1 + antagonist - human
2lq4 – hLPA1 second extracellular loop – NMR
4p0c – hLPA2/NHERF2
5xsz – LPA6A (mutant) – zebra fish

Proteopedia Resources

Category:Lysophosphatidic acid binding

Category:Lysophosphatidic acid

Butler University Proteopedia Pages

See also:

• Receptor
• Transmembrane (cell surface) receptors
• G protein-coupled receptors

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Student Contributors

Heather Hansen

Stephanie Kuhlman

Chandler Mitchell

Clayton Taylor