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| This Sandbox is Reserved from February 27 through August 31, 2023 for use in the course CH462 Biochemistry II taught by R. Jeremy Johnson at the Butler University, Indianapolis, USA. This reservation includes Sandbox Reserved 1765 through Sandbox Reserved 1795.
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To get started:
- Click the edit this page tab at the top. Save the page after each step, then edit it again.
- show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
- Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.
More help: Help:Editing
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SHOC2-PP1C-MRAS
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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Introduction
Relevance
Cell Proliferation
Cancer
Structure of Subunits
SHOC2
PP1C
MRAS
Binding of the Subunits
Signaling Cascade
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Autoinhibited Confirmation
Ras/Raf
GDP bound
Switch I and Switch II
Switch I Closed Conformation
Structure of Active Site
3-Metal Ion Catalysis
Hydrophobic Binding Site
Future Directions
This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:https://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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Protopedia Resources
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</StructureSection>
References
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Student Contributors
<student contributors/>
proteopedia link