7m5s | pdb_00007m5s

Herpes simplex virus 1 polymerase holoenzyme bound to mismatched DNA in editing conformation

spinqualitylabelsall models 7m5s, resolution 3.26Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7m5s is a 4 chain structure with sequence from Human alphaherpesvirus 1 strain KOS and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GS, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function H9E937_HHV1 Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication.[ARBA:ARBA00025601]

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