8bzy | pdb_00008bzy

Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy3 in occluded conformation

spinqualitylabelsall models 8bzy, resolution 3.24Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8bzy is a 2 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: PLC, SZU Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease S40A1_HUMAN Hemochromatosis type 4. The disease is caused by variants affecting the gene represented in this entry. Function S40A1_HUMAN Major iron transporter that plays a key role in balancing cellular and systemic iron levels (PubMed:29237594, PubMed:22682227, PubMed:15692071). Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity). When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342).[UniProtKB:Q9JHI9]

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