4v8q | pdb_00004v8q

Complex of SmpB, a tmRNA fragment and EF-Tu-GDP-Kirromycin with the 70S ribosome

spinqualitylabelsall models 4v8q, resolution 3.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4v8q is a 10 chain structure with sequence from Thermus thermophilus HB8. This structure supersedes the now removed PDB entries 4abr and 4abs. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GDP, KIR, MG, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RL29_THET8 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.[HAMAP-Rule:MF_00374] Publication Abstract from PubMed In bacteria, ribosomes stalled at the end of truncated messages are rescued by transfer-messenger RNA (tmRNA), a bifunctional molecule that acts as both a transfer RNA (tRNA) and a messenger RNA (mRNA), and SmpB, a small protein that works in concert with tmRNA. Here, we present the crystal structure of a tmRNA fragment, SmpB and elongation factor Tu bound to the ribosome at 3.2 angstroms resolution. The structure shows how SmpB plays the role of both the anticodon loop of tRNA and portions of mRNA to facilitate decoding in the absence of an mRNA codon in the A site of the ribosome and explains why the tmRNA-SmpB system does not interfere with normal translation. Decoding in the absence of a codon by tmRNA and SmpB in the ribosome.,Neubauer C, Gillet R, Kelley AC, Ramakrishnan V Science. 2012 Mar 16;335(6074):1366-9. PMID:22422985 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Elongation factor 3D structures Ribosome 3D structures Transfer RNA (tRNA)

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