1ji7
Crystal Structure of TEL SAM Polymer
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Overview
TEL is a transcriptional repressor that is a frequent target of, chromosomal translocations in a large number of hematalogical, malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional, regulatory proteins. The self-associating property of TEL-SAM is essential, for cell transformation in many, if not all of these diseases. Here we, show that the TEL-SAM domain forms a helical, head-to-tail polymeric, structure held together by strong intermolecular contacts, providing the, first clear demonstration that SAM domains can polymerize. Our results, also suggest a mechanism by which SAM domains could mediate the spreading, of transcriptional repression complexes along the chromosome.
Disease
Known diseases associated with this structure: Leukemia, acute myeloid, somatic OMIM:[600618]
About this Structure
1JI7 is a Single protein structure of sequence from Homo sapiens with SO4 as ligand. Full crystallographic information is available from OCA.
Reference
Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression., Kim CA, Phillips ML, Kim W, Gingery M, Tran HH, Robinson MA, Faham S, Bowie JU, EMBO J. 2001 Aug 1;20(15):4173-82. PMID:11483520
Page seeded by OCA on Mon Nov 12 17:40:56 2007
