4wt8 | pdb_00004wt8

Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex

spinqualitylabelsall models 4wt8, resolution 3.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4wt8 is a 18 chain structure with sequence from Thermus thermophilus HB8. This structure supersedes the now removed PDB entries 4wus, 4wwe and 4wwt. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 3V6, MG, PAR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RS2_THET8 Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit.[HAMAP-Rule:MF_00291_B] Publication Abstract from PubMed The ribosome is the target of a large number of antibiotics. Here, we report a 3.4-A-resolution crystal structure of bactobolin A bound to 70S ribosome-tRNA complex. The antibiotic binds at a previously unseen site in the 50S subunit and displaces tRNA bound at the P-site. It thus likely has a similar mechanism of action as blasticidin S despite binding to a different site. The structure also rationalizes previously identified resistance mutations. Bactobolin A Binds to a Site on the 70S Ribosome Distinct from Previously Seen Antibiotics.,Amunts A, Fiedorczuk K, Truong TT, Chandler J, Peter Greenberg E, Ramakrishnan V J Mol Biol. 2015 Jan 3. pii: S0022-2836(14)00654-8. doi:, 10.1016/j.jmb.2014.12.018. PMID:25562208 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Transfer RNA (tRNA)

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