4x88 | pdb_00004x88

E178D Selectivity filter mutant of NavMS voltage-gated pore

spinqualitylabelsall models 4x88, resolution 3.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4x88 is a 4 chain structure with sequence from Magnetococcus marinus MC-1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 1PE, 2CV, NA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0L5S6_MAGMM Publication Abstract from PubMed Voltage-gated sodium channels are essential for electrical signalling across cell membranes. They exhibit strong selectivities for sodium ions over other cations, enabling the finely tuned cascade of events associated with action potentials. This paper describes the ion permeability characteristics and the crystal structure of a prokaryotic sodium channel, showing for the first time the detailed locations of sodium ions in the selectivity filter of a sodium channel. Electrostatic calculations based on the structure are consistent with the relative cation permeability ratios (Na+ approximately Li+ >> K+, Ca2+, Mg2+) measured for these channels. In an E178D selectivity filter mutant constructed to have altered ion selectivities, the sodium ion binding site nearest the extracellular side is missing. Unlike potassium ions in potassium channels, the sodium ions in these channels appear to be hydrated and are associated with side chains of the selectivity filter residues, rather than polypeptide backbones. Molecular basis of ion permeability in a voltage-gated sodium channel.,Naylor CE, Bagneris C, DeCaen PG, Sula A, Scaglione A, Clapham DE, Wallace BA EMBO J. 2016 Feb 12. pii: e201593285. PMID:26873592 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Ion channels 3D structures

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