8hbh | pdb_00008hbh

Structure of human soluble guanylate cyclase in the NO-activated state at 3.1 angstrom

spinqualitylabelsall models 8hbh, resolution 3.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8hbh is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: G2P, HEM, MG, NO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease GCYA1_HUMAN Moyamoya disease with early-onset achalasia. The disease is caused by mutations affecting the gene represented in this entry. Function GCYA1_HUMAN Publication Abstract from PubMed Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO). The binding of NO to the haem of sGC induces a large conformational change in the enzyme and activates its cyclase activity. However, whether NO binds to the proximal site or the distal site of haem in the fully activated state remains under debate. Here, we present cryo-EM maps of sGC in the NO-activated state at high resolutions, allowing the observation of the density of NO. These cryo-EM maps show the binding of NO to the distal site of haem in the NO-activated state. NO binds to the distal site of haem in the fully activated soluble guanylate cyclase.,Liu R, Kang Y, Chen L Nitric Oxide. 2023 Mar 25;134-135:17-22. doi: 10.1016/j.niox.2023.03.002. PMID:36972843 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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