8bpc | pdb_00008bpc

Cryo-EM structure of the human SIN3B histone deacetylase core complex with SAHA at 2.8 Angstrom

spinqualitylabelsall models 8bpc, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8bpc is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA, SHH, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease SIN3B_HUMAN SIN3A-related intellectual disability syndrome due to a point mutation. Function SIN3B_HUMAN Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.[UniProtKB:Q62141]

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