8d2x | pdb_00008d2x

Zebrafish MFSD2A isoform B in inward open ligand 3C conformation

spinqualitylabelsall models 8d2x, resolution 3.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8d2x is a 3 chain structure with sequence from Danio rerio and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: LMT, ZGS Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function NLS1B_DANRE Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid.[UniProtKB:Q9DA75]

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