7xuj | pdb_00007xuj

Human SLC26A3 in complex with UK5099

spinqualitylabelsall models 7xuj, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7xuj is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: I2R, Y01 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease S26A3_HUMAN Congenital chloride diarrhea. The disease is caused by variants affecting the gene represented in this entry. Function S26A3_HUMAN Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:16606687, PubMed:19321737, PubMed:22159084, PubMed:22627094). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).[UniProtKB:Q9WVC8]

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