5bmf | pdb_00005bmf

Crystal Structure of a Theophylline binding antibody Fab fragment

spinqualitylabelsall models 5bmf, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5bmf is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 4TJ Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Knowledge of the three-dimensional structure of the antigen-binding region of antibodies enables numerous useful applications regarding the design and development of antibody-based drugs. We present a knowledge-based antibody structure prediction methodology that incorporates concepts that have arisen from an applied antibody engineering environment. The protocol exploits the rich and continuously growing supply of experimentally derived antibody structures available to predict CDR loop conformations and the packing of heavy and light chain quickly and without user intervention. The homology models are refined by a novel antibody-specific approach to adapt and rearrange sidechains based on their chemical environment. The method achieves very competitive all-atom root mean square deviation values in the order of 1.5 A on different evaluation datasets consisting of both known and previously unpublished antibody crystal structures. MoFvAb: modeling the Fv region of antibodies.,Bujotzek A, Fuchs A, Qu C, Benz J, Klostermann S, Antes I, Georges G MAbs. 2015 Jul 15:0. PMID:26176812 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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