5oga | pdb_00005oga

Structure of minimal i-motif domain

spinqualitylabelsall models 5oga Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5oga is a 1 chain structure with sequence from Synthetic construct. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: DNR, THM Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed We report here the solution structure of several repetitive DNA sequences containing d(TCGTTCCGT) and related repeats. At physiological pH, these sequences fold into i-motif like quadruplexes in which every two repeats a globular structure is stabilized by two hemiprotonated C:C(+) base pairs, flanked by two minor groove tetrads resulting from the association of G:C or G:T base pairs. The interaction between the minor groove tetrads and the nearby C:C(+) base pairs affords a strong stabilization, which results in effective pHT values above 7.5. Longer sequences with more than two repeats are able to fold in tandem, forming a rosary bead-like structure. Bioinformatics analysis shows that these sequences are prevalent in the human genome, and are present in development-related genes. Prevalent Sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH.,Mir B, Serrano I, Buitrago D, Orozco M, Escaja N, Gonzalez C J Am Chem Soc. 2017 Oct 11;139(40):13985-13988. doi: 10.1021/jacs.7b07383. Epub, 2017 Sep 27. PMID:28933543 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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