7vm9 | pdb_00007vm9

Solution NMR structures of DNA minidumbbell formed with two regular CTTTG pentaloops

spinqualitylabelsall models 7vm9 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7vm9 is a 1 chain structure with sequence from Synthetic construct. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Minidumbbell (MDB) is a noncanonical DNA structure found to form in several pyrimidine-rich short tandem repeats associated with neurodegenerative diseases. The most recently reported MDB contains two pentaloops formed by ATTCT repeats. Here, we studied the effects of a purine residue and a backbone discontinuous site on the structure and thermal stability of MDBs containing two pentaloops. It was found that a purine as the fourth loop residue improved the thermal stability of MDBs containing two regular pentaloops, while a backbone discontinuous site between the third and fourth, or between the fourth and fifth loop residues enhanced the thermal stability of MDBs containing a regular and a quasi pentaloops. The results of this study provide new insights into the sequence criteria and structural basis of MDBs. A purine and a backbone discontinuous site alter the structure and thermal stability of DNA minidumbbells containing two pentaloops.,Ngai CK, Lam SL, Lee HK, Guo P FEBS Lett. 2022 Jan 21. doi: 10.1002/1873-3468.14293. PMID:35060128 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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