Lactate dehydrogenase 3D structures

3D structures of lactate dehydrogenase

Updated on 15-June-2023

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• L-LDH
  • 4l4r, 4ojn, 6zzr – hLDH A chain – human
    
  • 2ldx – C4-LDH - mouse
    
  • 5k0z – LDH B chain – chicken
    
  • 1ldm, 6ldh, 8ldh – sdM4-LDH – spiny dogfish
    
  • 2e37, 2v6m – TtL-LDH – Thermus thermophilus
    
  • 3zzn, 4a73– TtL-LDH (mutant)
    
  • 2x8l, 1ceq – PfL-LDH – Plasmodium falciparum
    
  • 2zqy, 2zqz, 1llc, 6jml – LcL-LDH – Lactobacillus casei
    
  • 6j9s - LcL-LDH (mutant)
    
  • 3d0o - SaL-LDH – Staphylococcus aureus
    
  • 2v65 - L-LDH A chain – Champsocephalus gunnari
    
  • 2v6b – L-LDH – Deinococcus radiodurans
    
  • 4nd5 – CpLDH – Cryptosporidium parvum
    
  • 1sov, 1pze - TgL-LDH – Toxoplasma gondii
    
  • 1v6a – L-LDH A chain – Cyprinus carpio
    
  • 1y6j – L-LDH – Clostridium thermocellum
    
  • 1ldb - GsL-LDH – Geobacillus stearothermophilus
    
  • 4m1q - BseL-LDH – Bacillus selenitireducens
    
  • 3pqe – BsL-LDH (mutant) – Bacillus subtilis
    
  • 4lmr, 4ln1 - LDH – Bacillus cereus
    
  • 3vpg – TcLDH – Thermus caldophilus
    
  • 3wsv – EmLDH – Enteroccocus mundtii
    
  • 4uum – TvL-LDH – Trichomonas vaginalis
    
  • 4uul – TvL-LDH (mutant)
    
  • 5hs4, 6txr - PvL-LDH – Plasmodium vivax
    
  • 6or9 – LDH – Trichoplusia
    
  • 7w8a – LDH – Babesia orientalis
    
  • 6k12 – BmLDH – Babesia microti
    
  • 6j9d – BmLDH (mutant)
    
  • 6vdh, 6vdi – ApLDH - Apicomplexa
    
  • 8ab2 – CaL-LDH – Cyanobacterium aponium
    
  • 7wn9 – DdLDH – Dictyostelium discoideum
    
• L-LDH from yeast (cytochrome b2)
  • 1kbj - LDH FMN-binding domain
    
  • 1sze, 1lco, 2oz0 - LDH FMN-binding domain (mutant)
    
  • 1kbi - LDH FMN-binding domain + pyruvate
    
  • 1szf, 1ldc - LDH FMN-binding domain (mutant) + pyruvate
    
  • 1szg - LDH FMN-binding domain + sulfo-FMN
    
  • 3ks0 - LDH residues 86-180 + flavocytochrome b2 heme domain + FAB B2B4
• L-LDH binary complex
  • 4ajp, 4m49, 4qsm, 4qt0, 5w8h, 5w8i, 5w8j, 6q13, 6sbv – hLDH A chain + inhibitor
    
  • 4l4s – hLDH A chain + NAD
    
  • 5zje - hL-LDH A chain + malonate
    
  • 5zjf - hL-LDH A chain + machilin
    
  • 7dbk – hLDH B chain + NAD
    
  • 7epm – hLDH C chain + NAD
    
  • 4i8x, 4i9h, 4i9n, 4i9u – rLDH A chain + pyridine derivative - rabbit
    
  • 6p6u – rLDH A chain + AMP
    
  • 7p4g – rLDH A chain + citrate
    
  • 4aj1, 4aj2, 4aj4, 4aje, 4ajh, 4aji, 4ajj, 4ajk, 4ajl, 4ajn, 4ajo, 4al4, 5kkc – raL-LDH A chain + inhibitor – rat
    
  • 5es3 – raL-LDH + oxamate
    
  • 5nqb – raL-LDH A chain (mutant) + malonate
    
  • 4b7u – PfL-LDH + bicine
    
  • 1cet - PfL-LDH + chloroquine
    
  • 1t2c - PfL-LDH + NAD
    
  • 3zh2 - PfL-LDH + DNA aptamer
    
  • 1ez4 - L-LDH + NAD – Lactobacillus pentosus
    
  • 1lld, 2ldb - GsL-LDH + NAD
    
  • 2a92 – PvL-LDH + NAD
    
  • 2a94, 2aa3 - PvL-LDH + NAD-analog
    
  • 5hru, 5hto - PvL-LDH + DNA
    
  • 1u4o, 1u4s, 1u5a, 1xiv – PfL-LDH + inhibitor
    
  • 2xxb – TtL-LDH (mutant) + AMP
    
  • 3pqf, 6j9u – BsL-LDH (mutant) + NAD
    
  • 6j9t - LcLDH + fructose-bisphosphate
    
  • 6j9u – LcLDH (mutant) + pyruvate
    
  • 4uun – TvL-LDH + NAD
    
  • 6h9s – LDH + NAD – Petrotoga mobilis
    
  • 6vdj – ApLDH + NAD derivative
    
  • 7nay – LDH + NAD – Selenomonas ruminatium
    
  • 8grv – DdLDH + NAD
    
• L-LDH ternary complex with inhibitor
  • 1t2f - hL-LDH B chain + azole derivative + NAD
    
  • 1i0z - hL-LDH H chain + oxamate + NAD
    
  • 1i10 - hL-LDH M chain + oxamate + NAD
    
  • 4qo7, 4qo8, 4r68, 4r69, 4rls, 4zvv, 5ixs, 5ixy, 5w8k, 5w8l, 6bad, 6bag, 6bax, 6baz, 6bb0, 6bb1, 6bb2, 6bb3, 6q0d, 6sbu, 7m2n - hL-LDH A chain + inhibitor + NAD
    
  • 5zjd - hL-LDH A chain + malonate + NAD
    
  • 9ldb, 9ldt, 6cep, 5yta - pL-LDH + oxamate + NAD – pig
    
  • 3h3f – rL-LDH A chain + oxamate + NAD
    
  • 5nqq - rL-LDH A chain + oxalacetate + NAD
    
  • 1u5c - PfL-LDH + inhibitor + NAD
    
  • 1t24, 1t25, 1t26 - PfL-LDH + azole derivative + NAD
    
  • 1t2e - PfL-LDH (mutant) + oxamate + NAD
    
  • 1ldg, 4plz - PfL-LDH + oxamate + NAD
    
  • 1t2d - PfL-LDH + oxalate + NAD
    
  • 2xxj – TtL-LDH (mutant) + oxamate + NAD
    
  • 2v7p - TtL-LDH + oxamate + NAD
    
  • 3om9, 3czm – TgL-LDH + OXQ + NAD
    
  • 1sow, 1pzh - TgL-LDH + oxalate + NAD
    
  • 1pzf - TgL-LDH + oxalate + NAD-analog
    
  • 1pzg - TgL-LDH + sulfate + NAD-analog
    
  • 4nd1 - CpLDH + oxamate + NAD
    
  • 3wsw – EmL-LDH + NAD + fructose diphosphate
    
  • 1oc4 – L-LDH + oxamate + NAD – Plasmodium berghei
    
  • 1a5z - L-LDH + oxamate + NAD – Thermotoga maritima
    
  • 1lth - L-LDH + oxamate + NAD – Bifidobacterium longum
    
  • 1ldn - GsL-LDH + oxamate + NAD
    
  • 4plc, 4plf – ApLDH + NAD + pyruvate - Apicomplexa
    
  • 4plg – ApLDH + NAD + oxamate
    
  • 5a1t – TvL-LDH + NAD + oxamate
    
  • 6k13 – BmLDH + NAD + oxamate
    
  • 6ct6 – LDH + NAD + oxamate – Eimeria maxima
    
  • 7qh2 – LDH + FAD + Fe – Acetobacterium woodii – Cryo EM
    
• L-LDH ternary complex with reactants
  • 5ldh - pLDH + citrate + NAD-analog
    
  • 3ldh - sdLDH + pyruvate + NAD
    
  • 3h3j – SaL-LDH (mutant) + pyruvate + NAD
    
  • 3d4p - SaL-LDH + pyruvate + NAD
    
  • 2fn7, 4nd3 - CpLDH + lactate + NAD
    
  • 4nd2 - CpLDH + pyruvate + NAD-analog
    
  • 4nd4 - CpLDH + pyruvate + NAD
    
  • 3pqd - BsLDH + fructose-bisphosphate + NAD
• L-LDH quaternary complex
  • 4jnk, 6mv8, 6mva - hL-LDH A chain + inhibitor + lactate + NAD
    
  • 4okn - hL-LDH A chain + katamycin+ oxalate + NAD
    
  • 7dbj - hL-LDH B chain + inhibitor+ oxamate + NAD
    
  • 3vph - TcL-LDH + oxamate + NAD + fructose diphosphate
    
  • 6trx - PvL-LDH + GMP + UMP + AMP + CMP + malaria biomarker
    
  • 8ab3 - CaL-LDH + inhibitor+ oxamate + NAD
    
• D-LDH
  • 3kb6 – D-LDH + lactate + NAD – Aquifex aeolicus
    
  • 1j49 – LdD-LDH + sulfate + NAD – Lactobacillus delbrueckii
    
  • 1j4a - LdD-LDH + sulfate
    
  • 4prk, 4prl - D-LDH – Lactobacillus jensenii
    
  • 3wx0, 5z1z – EcD-LDH – Escherichia coli
    
  • 1f0x – EcD-LDH + FAD
    
  • 2dld - D-LDH + oxamate + NAD – Lactobacillus helveticus
    
  • 6abi – FnD-LDH – Fusobacterium nucleatum
    
  • 5z21 – FnD-LDH + NAD + oxamate
    
  • 6abj – PaD-LDH – Peudomonas aeruginosa
    
  • 5z20 – FnD-LDH + NAD + oxamate
    
  • 4xkj – D-LDH + NAD – Sporolactobacillus inulinus
    
  • 4cuj – SeD-LDH – Salmonella enterica
    
  • 4cuk – SeD-LDH + NAD
    
  • 7jp2 – D-LDH – Treponema pallidum
    
• L-LDH II
  • 1x0a, 1vbi – TtL-LDH II
• L-Lactate/malate dehydrogenase
  • 1hye, 1hyg – L-LDH/MDH – Methanocaldococcus jannaschi
    
  • 2g8y - EcL-LDH/MDH

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman