Lactoferrin

spinqualitylabelsall models Human lactoferrin complex with oxalate and Fe+3 ion (PDB entry 1bka) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Lactoferrin or lactotransferrin (LTF) is found in secretory fluids. LTF interacts with DNA, RNA, polysaccharides and heparin. For detailed discussion of human lactoferrin see Human lactoferrin. Relevance LTF is inhibited by nonsteroidal anti-inflammatory drugs (NSAID) like aspirin. It is a component of the immune system and has antimicrobial activity. LTF can be used as a marker for inflammatory bowel disease. Structural highlights LTF is a bilobal protein with the N-terminal half and the C-terminal half called N-lobe and C-lobe. LTF binds with high affinity Fe+3 ion and an anion in both its N-lobe and its C-lobe. The binding site is between the 2 domains of each lobe. N-lobe binding site. The anion binds the Fe+3 in a 1,2 bidendate fashion. C-lobe binding site. The anion binds the Fe+3 in a 1,2 bidendate fashion.

3D Structures of lactoferrin

Updated on 15-June-2023

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• Apo lactoferrin
  • Human lactoferrin, 1lfg, 1lfh – hLTF - human
    
  • 1u62, 1xv4, 1xv7, 1z6v, 1z6w - hLTF peptide – NMR
    
  • 1i6b, 1b7u – hoLTF – horse
    
  • 1dtz – cLTF - camel
    
  • 1lfc – bLTF residues 17-41 – bovine – NMR
    
  • 4oqo – bLTF C lobe
    
• Lactoferrin
  • 2bjj, 1sqy, 1n76– hLTF + 2Fe
    
  • 1b0l - hLTF (mutant) + 2Fe
    
  • 1fck – hLTF + 2Ce
    
  • 1lfi - hLTF + 2Cu
    
  • 1lct - hLTF N lobe + 2Fe
    
  • 1h43, 1h44, 1h45, 1l5t, 1eh3, 1vfd, 1vfe, 1hse, 1dsn - hLTF N lobe (mutant) + 2Fe
    
  • 1blf – bLTF + 2Fe
    
  • 1sdx - bLTF C lobe + 3Zn
    
  • 5cry, 5hbc, 7enu, 7equ, 7ev0, 7evq, 7fdw - bLTF C lobe + Fe+3
    
  • 1nkx, 3u8q - bLTF C lobe + 2Zn + Fe
    
  • 1b1x, 1f9b – hoLTF + 2Fe
    
  • 1qjm – hoLTF + 2Sm
    
  • 1ce2, 1biy – buLTF + 2Fe - buffalo
    
  • 1i6q – cLTF + 2Fe
    
  • 1jw1 – LTF + 2Fe – goat
• Lactoferrin complex
  • 1bka - hLTF + 2Fe + oxalate
    
  • 7jrd - hLTF + 2Fe + LTF-binding protein
    
  • 7n88 - hLTF + 2Fe + LTF-binding protein – Cryo EM
    
  • 1lcf - hLTF + 2Cu + oxalate
    
  • 2pms – hLTF N lobe + PSPA transferring-binding domain + 2Zn + 2Fe
    
  • 3sdf – bLTF C lobe + lipoteichoic acid + 2Zn + Fe
    
  • 4n6p - bLTF C lobe + meclofenamic acid + 2Zn + Fe
    
  • 4ned - bLTF C lobe + fenoprofen + 2Zn + Fe
    
  • 3rgy - bLTF C lobe + lipopolysaccharide + Zn + Fe
    
  • 3kj7, 3k0v, 2q8j, 2o51, 2nwj, 2dxy, 2dwj, 2dsf, 2ds9, 2hca, 2dqv, 2dp8, 2g93, 2ays, 2alu, 2dwi, 2dyx, 2o1l, 2p1s - bLTF C lobe + polysaccharide + 2Zn + Fe
    
  • 2o1l - bLTF C lobe + polysaccharide + Zn + Fe
    
  • 2fa7, 2b65 - bLTF C lobe + polysaccharide + 3Zn + Fe
    
  • 2dvc, 2dwa, 2dwh, 2e0s, 2e1s, 2h4i, 2px1 - bLTF C lobe + saccharide + 2Zn + Fe
    
  • 2dxr - bLTF C lobe + sorbitol+ 2Zn + Fe
    
  • 3iaz, 3ib0, 3ib1 - bLTF C lobe (mutant) + NSAID + 2Zn + Fe
    
  • 3e9x, 2qje, 2zmb, 3crb, 2nuv, 4fim, 4fjp, 4for, 4g2z, 4g77, 4g8h, 4grk, 3taj - bLTF C lobe + NSAID + 2Zn + Fe
    
  • 3o97, 3mjn, 3cfl, 2ocu, 3tod, 3tus – bLTF C lobe + inhibitor + 2Zn + Fe
    
  • 3ib2 - bLTF C lobe (mutant) + inhibitor + 2Zn + Fe
    
  • 2doj - bLTF C lobe + adenosine + 2Zn + Fe
    
  • 3ugw - bLTF C lobe + deoxycytidine + 2Zn + Fe
    
  • 3ci8 - bLTF C lobe + niacin + 2Zn + Fe
    
  • 2r9j - bLTF C lobe + nicotinamide + 2Zn + Fe
    
  • 2r71 - bLTF C lobe + inositol + 2Zn + Fe
    
  • 3uk4 - bLTF C lobe + pentatriol + 2Zn + Fe
    
  • 3usd - bLTF C lobe + pyridine derivative + 2Zn + Fe
    
  • 3ttr - bLTF C lobe + anasthetic + 2Zn + Fe
    
  • 3vdf - bLTF C lobe + diaminopimelic acid + 2Zn + Fe
    
  • 4dxu - bLTF C lobe + caproic acid + 2Zn + Fe
    
  • 3v5a - bLTF C lobe + γ-amino butyric acid + 2Zn + Fe
    
  • 3u72, 4dig - bLTF C lobe + polypeptide + 2Zn + Fe
    
  • 3ptl – bLTF peptide + proteinase K
    
  • 1bjr - buLTF peptide + proteinase K
    
  • 1b7z - hoLTF + 2Fe + oxalate
    
  • 3cr9 – hoLTF + inhibitor + 2Fe
    
  • 2j4u – cLTF N terminal + OMPC
    

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