1ngt | pdb_00001ngt

The Role of Minor Groove Functional Groups in DNA Hydration

spinqualitylabelsall models 1ngt, resolution 2.04Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1ngt is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MG, MTR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Here we describe the crystal structure of modified [d(CGCGAATTCGCG)]2 refined to 2.04 A. The modification, which affects only the two thymines at the central ApT step, involves isosteric removal of the 2-keto oxygen atoms and substitution of the N1 nitrogen with carbon. The crystal structure reveals the ability of this modified thymine to effectively base pair with adenine in [d(CGCGAAtTCGCG)]2. The structure also suggests that the minor groove 'spine of hydration' is destabilized but essentially intact. The role of minor groove functional groups in DNA hydration.,Woods KK, Lan T, McLaughlin LW, Williams LD Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:12595562 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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