8j0r | pdb_00008j0r

Structure of human TFAP2A in complex with DNA

spinqualitylabelsall models 8j0r, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8j0r is a 4 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.1Å Ligands: GOL, PEG, PG3, PG4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease AP2A_HUMAN Branchio-oculo-facial syndrome. The disease is caused by variants affecting the gene represented in this entry. Function AP2A_HUMAN Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.

Proteopedia Page Contributors and Editors (what is this?)

OCA