5en6 | pdb_00005en6

Crystal structure of the Smu1-RED complex (SeMet) of Caenorhabditis elegans

spinqualitylabelsall models 5en6, resolution 3.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5en6 is a 4 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.103Å Ligands: MSE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SMU1_CAEEL Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Selectively regulates alternative splicing of unc-52 exon 17 (PubMed:11438655, PubMed:15254247). Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17 and enhance the effects of unc-52 mutations that affect the exon 16 splice donor site (PubMed:11438655, PubMed:15254247). In contrast, smu-1 mutants do not suppress unc-52 nonsense mutations in exon 18 (PubMed:11438655).[UniProtKB:Q2TAY7]

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