Nitroreductase

spinqualitylabelsall models E. coli nitroreductase dimer containing FMN and nicotinic acid (PDB entry 1icr) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Nitroreductase or oxygen-insensitive NAD(P)H nitroreductase (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO2 group. The NO2 group is reduced to hydroxylamine. NR uses FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. Relevance NR is of special interest due to its potential use as activator of prodrugs in cancer therapy. Structural highlights NR cofactor FMN is bound directly to one subunit while the ligand - nicotinic acid - interacts with both subunits. Water molecules are shown as red spheres. 3D structures of nitroreductase Nitroreductase 3D structures

3D structures of nitroreductase

Updated on 19-July-2023

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• Nitroreductase
  • Nitroreductase 3D structures, 1ds7 – EcNR minimal + FMN – Escherichia coli
    
  • 3bm2 – EcNR minimal -FMN
    
  • 1nec, 1kqd – EclNR + FMN – Enterobacter cloacae
    
  • 1kqb, 5j8g– EclNR + FMN + benzoate derivative
    
  • 1kqc – EclNR + FMN + acetate
    
  • 1ywq, 2i7h – NR + FMN – Bacillus cereus
    
  • 5hdj – NR + FMN – Bacillus megaterium
    
  • 2b67 – NR + FMN – Streptococcus pneumonia
    
  • 3ek3, 3hoi – NR + FMN – Bacterioides fragilis
    
  • 3g14 – NR – Clostridium novyi
    
  • 3h4o, 3koq - NR + FMN – Clostridium difficile
    
  • 3gr3 – NR + FMN – Bartonella henselae
    
  • 3hzn – NR – Salmonella typhimurium
    
  • 3k6h – NR + FMN – Agrobacterium tumefaciens
    
  • 2wzv, 2ymv – MsNR + FMN – Mycobacterium smegmatis
    
  • 2wzw - MsNR + FMN + NADPH
    
  • 3of4 – NR + FMN + FAD – Idiomarina loihiensis
    
  • 3n2s – NR + FMN – Bacillus subtilis
    
  • 3pxv – NR + FMN – Desulfitobacterium hafniense
    
  • 3r5l, 3r5p - MtNR – Mycobacterium tuberculosis
    
  • 3ge6 – NR + FMN – Exiguobacterium sibiricum
    
  • 4dn2 – NR + FMN – Geobacter metallireducens
    
  • 5ko7, 5ko8, 5krd – NR + FMN – Haliscomenobacter hydrossis
    
  • 7dp0 – SpNR + FMN – Sphingopyxis
    
  • 7dp1, 7dp2 – SpNR (mutant) + FMN
    
• Copper-induced nitroreductase
  • 2wqf – LlNR + FMN – Lactococcus lactis
    
  • 4bn6 – LlNR + FMN + chloramphenicol
    
  • 4bn7, 4bn8 – LlNR + FMN + phenol derivative
    
  • 4bn9 – LlNR + FMN + nicotinic acid
    
  • 4bnb – LlNR + FMN + nitroquinoline
    
• Nitrobenzoate nitroreductase
  • 4z85 – NR – Psudomonas fluorescens
    

• Oxygen-insensitive NADPH nitroreductase
  • 1f5v, 1oo5, 7q0o – EcNR + FMN
    
  • 3x21, 3x22 – EcNR (mutant) + FMN
    
  • 7z0w – EcNR + FMN + adenosine derivative
    
  • 7xww – EcNR + FMN + pyridine derivative
    
  • 8c5e, 8ccv, 8cj0 – EcNR (mutant) + FMN + nicotinic acid
    
  • 1ylr, 1ylu - EcNR + FMN + acetate
    
  • 8c5f, 8c5p – EcNR (mutant) + FMN + acetate
    
  • 8og3 – EcNR (mutant) + FMN + citrate
    
  • 7niy – EcNR (mutant) + FMN + imidazole
    
  • 8ajx – EcNR + FMN + fumarate
    
  • 7x32 – EcNR + FMN + berberine
    
  • 7nb9 – EcNR + FMN + nitrofurantoin
    
  • 7nmp, 7nnx – EcNR + FMN + quinone derivative
    
  • 1icr, 1icu, 1icv, 5j8d – EcNR + FMN + NAD derivative
    
  • 1ooq – EcNR + FMN + dicoumarol
    
  • 1oo6, 1oon, 1idt – EcNR + FMN + benzamide derivative
    
  • 1yki – EcNR + FMN + antibiotic
    
  • 6czp – VvNR + FMN – Vibrio vulnificus
    
  • 7uwt – VvNR (mutant) + FMN
    
  • 3qdl – NR + FMN – Helicobacter pylori
    
• Deazaflavin-dependent nitroreductase
  • 3r5r, 3r5w, 7kl8 – MtNR + coenzyme F420
    
• NADPH nitroreductase
  • 7tmf, 7tmg – NR + FMN – Klebsiella pneumoniae
    
• NADPH-flavin nitroreductase
  • 5uu6 – NR + FMN – Vibrio parahaemolyticus
    

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