5gpn | pdb_00005gpn

Architecture of mammalian respirasome

Loading... Status: waiting for Mol* initialization Structural highlights 5gpn is a 13 chain structure with sequence from Bos taurus and Sus scrofa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 5.4Å Ligands: CU, FES, FMN, HEA, HEC, HEM, MG, NDP, SF4, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function K7GR43_PIG Publication Abstract from PubMed The respiratory chain complexes I, III and IV (CI, CIII and CIV) are present in the bacterial membrane or the inner mitochondrial membrane and have a role of transferring electrons and establishing the proton gradient for ATP synthesis by complex V. The respiratory chain complexes can assemble into supercomplexes (SCs), but their precise arrangement is unknown. Here we report a 5.4 A cryo-electron microscopy structure of the major 1.7 megadalton SCI1III2IV1 respirasome purified from porcine heart. The CIII dimer and CIV bind at the same side of the L-shaped CI, with their transmembrane domains essentially aligned to form a transmembrane disk. Compared to free CI, the CI in the respirasome is more compact because of interactions with CIII and CIV. The NDUFA11 and NDUFB9 supernumerary subunits of CI contribute to the oligomerization of CI and CIII. The structure of the respirasome provides information on the precise arrangements of the respiratory chain complexes in mitochondria. The architecture of the mammalian respirasome.,Gu J, Wu M, Guo R, Yan K, Lei J, Gao N, Yang M Nature. 2016 Sep 29;537(7622):639-43. doi: 10.1038/nature19359. PMID:27654917 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Proteopedia Page Contributors and Editors (what is this?)

OCA