8e22 | pdb_00008e22

VPS37A_21-148

spinqualitylabelsall models 8e22 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8e22 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease VP37A_HUMAN Autosomal recessive spastic paraplegia type 53. The disease is caused by variants affecting the gene represented in this entry. Function VP37A_HUMAN Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

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