Structural highlights
8imx is a 7 chain structure with sequence from Clavularia sp., Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | Electron Microscopy, Resolution 2.85Å |
| Ligands: | 05E, 6OU, 80T, 80Y, 81Q, AJP, CA, LBN, MG, NAG, PA1, Y01 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
GFPL_CLASP ULBP2_HUMAN Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.[1]
References
- ↑ Sutherland CL, Chalupny NJ, Schooley K, VandenBos T, Kubin M, Cosman D. UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. J Immunol. 2002 Jan 15;168(2):671-9. PMID:11777960 doi:10.4049/jimmunol.168.2.671
