Pannexin

spinqualitylabelsall models Human pannexin 1 complex with lipid (PDB ID (7f8o) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Pannexin (PNX) is a family of single membrane channel-forming glycoprotein. The family is comprised of 3 members. PNX1 is expressed in mammalian tissue and plays a role in releasing signals for apoptotic cell clearance. In addition, PNX1 plays a role in propagation of calcium waves, regulation of vascular tone, mucociliary lung clearance, taste-bud function. PNX1 mediates release of ATP which acts as a signal recruiting macrophages to apoptotic cells. PNX1 activation requires cleavage of its C-terminal tail by caspase. Relevance PNX1 acts like a tumor suppressor in glioma and is involved in melanoma, epilepsy, glaucoma, hypertension. Alzheimer, diabetes and other diseases. Structural highlights The 3D structure of human PNX1 shows the pore to constitute 7 subunits. The C-terminal of PNX1 is cleaved by caspase to produce an active PNX1. The pore transmembrane domains are occupied by lipid molecules which interact predominantly with hydrophobic residues. 3D structures of pannexin Updated on 21-August-2023 6ltn, 6lto, 6m02, 6m66, 6v6d, 7dwb, 7f8j, 7f8n, 7f8o – hPNX1 residues 1-426 – human - Cryo EM 6m67, 6m68 – hPNX1 (mutant) residues 1-426 – Cryo EM 7wsv – hPNX1 residues 21-426 – Cryo EM 6wbf, 6wbg, 6wbk – hPNX1 residues 1-373 – Cryo EM 6wbi, 6wbl, 6wbm, 6wbn – hPNX1 (mutant) residues 1-373 – Cryo EM 7xlb, 8f7c – hPNX2 - Cryo EM 7xl6 – hPNX3 - Cryo EM 8a3b – mPNX1 – mouse - Cryo EM 6uzy, 6vd7 – PNX1 – western clawed frog – Cryo EM

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