8e05 | pdb_00008e05

Structure of dimeric LRRK1

spinqualitylabelsall models 8e05, resolution 4.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8e05 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.6Å Ligands: GDP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease LRRK1_HUMAN Osteosclerotic metaphyseal dysplasia. The disease is caused by variants affecting the gene represented in this entry. Function LRRK1_HUMAN Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts.[UniProtKB:Q3UHC2]

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