2fe5 | pdb_00002fe5

The Crystal Structure of the Second PDZ Domain of Human DLG3

spinqualitylabelsall models 2fe5, resolution 1.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2fe5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.1Å Ligands: GOL, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease DLG3_HUMAN Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:300850. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Function DLG3_HUMAN Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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