| Polyhedrin is a viral protein in cytoplasmic polyhedrosis viruses which parasitize insects. Polyhedrin forms a protective layer around a virus and resists its solubilization and thus ensures its long-term viability[1].
Relevance
Polyhedrins protect viruses which cause disease in silkworm[2].
Structural highlights
The biological assembly of Uranotaenia sapphirina cypovirus Polyhedrin is homotrimer (PDB code 4s1k). ATP binding site[3]. Water molecules are shown as red spheres. Mg coordination site.
- ↑ Rohrmann GF. Polyhedrin structure. J Gen Virol. 1986 Aug;67 ( Pt 8):1499-513. doi: 10.1099/0022-1317-67-8-1499. PMID:3525744 doi:https://dx.doi.org/10.1099/0022-1317-67-8-1499
- ↑ Kunimi Y. Current status and prospects on microbial control in Japan. J Invertebr Pathol. 2007 Jul;95(3):181-6. doi: 10.1016/j.jip.2007.03.007. Epub, 2007 Mar 25. PMID:17462666 doi:https://dx.doi.org/10.1016/j.jip.2007.03.007
- ↑ Ginn HM, Messerschmidt M, Ji X, Zhang H, Axford D, Gildea RJ, Winter G, Brewster AS, Hattne J, Wagner A, Grimes JM, Evans G, Sauter NK, Sutton G, Stuart DI. Structure of CPV17 polyhedrin determined by the improved analysis of serial femtosecond crystallographic data. Nat Commun. 2015 Mar 9;6:6435. doi: 10.1038/ncomms7435. PMID:25751308 doi:https://dx.doi.org/10.1038/ncomms7435
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3D structures of polyhedrin
Updated on 04-September-2023
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- Polyhedrin
- 4s1k – PH – wiseana signata nucleopolyhedrovirus
- 2wux, 2wuy, 3jw6 – PH – autographa californica nucleopolyhedrovirus
- 5gqk, 5yha, 5yhb, 7xhr, 7xws – bmcvPH – bombyx mori cypovirus
- 5a9b, 5gqi, 5gqj, 5gqn, 5yr1, 5yr9, 5yra, 5yrb, 5yrc, 5yrd, 6lee – bmcvPH (mutant)
- 5a8s, 5a8t, 5a9c – PH (mutant) – antheraea mylitta cypovirus
- 5a8u, 5a8v – PH – orgyia pseudotsugata cypovirus
- 5g0z, 5g3x – PH – cydia pomonella granulovirus
- 8bbt, 8bc5, 8bck, 8bcl – PH – tipula oleracea nudivirus
- Polyhedrin complex
- 4s1k, 4s1l, 4zqx – PH + ATP – uranotaenia sapphirina cypovirus
- 5a99 – obcvPH + ATP – operophtera brumata cypovirus
- 4ots, 4otv, 4x35, 5a9p, 5mqw – obcvPH + ATP + GTP
- 5axv – bmcvPH (mutant) + CTP
- 5gql – bmcvPH + ATP + CTP
- 5axu – bmcvPH (mutant) + ATP + CTP
- 2oh5, 2oh6, 2oh7, 5exy, 5exz, 5gqm – bmcvPH + ATP + GTP + CTP
- 5a96 – PH + GTP – lymantria dispar cypovirus
- 5a98 – PH + ATP – trichoplusia ni cypovirus
- 5a9a – PH + UTP – simullium ubuquitum cypovirus
References
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