3ndb | pdb_00003ndb

Crystal structure of a signal sequence bound to the signal recognition particle

spinqualitylabelsall models 3ndb, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3ndb is a 3 chain structure with sequence from Methanocaldococcus jannaschii and Methanocaldococcus jannaschii DSM 2661. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3Å Ligands: PO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SRP19_METJA Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP (By similarity). Publication Abstract from PubMed The signal recognition particle (SRP) recognizes and binds the signal sequence of nascent proteins as they emerge from the ribosome. We present here the 3.0-A structure of a signal sequence bound to the Methanococcus jannaschii SRP core. Structural comparison with the free SRP core shows that signal-sequence binding induces formation of the GM-linker helix and a 180 degrees flip of the NG domain-structural changes that ensure a hierarchical succession of events during protein targeting. Structural basis of signal-sequence recognition by the signal recognition particle.,Hainzl T, Huang S, Merilainen G, Brannstrom K, Sauer-Eriksson AE Nat Struct Mol Biol. 2011 Mar;18(3):389-91. Epub 2011 Feb 20. PMID:21336278 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Signal recognition particle protein

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